OBJECTIVE: We used voxel-based morphometry (VBM) to assess the pattern of regional grey matter (GM) loss in patients with paediatric multiple sclerosis (MS) and its relation with the Expanded Disability Status Scale (EDSS) score, disease duration, and the extent of T2 lesion load (LL).

METHODS: From 28 patients with paediatric relapsing-remitting MS (16 girls; mean age = 14.4 years, range = 7 to 16 years) and 21 matched controls, dual-echo and three-dimensional T1-weighted magnetization prepared rapid acquisition gradient echo sequences were acquired. T2 LL was measured using a local thresholding segmentation technique. Data were analyzed using an optimized VBM analysis and statistical parametric mapping.............

To read the complete abstract please go to MSRC: MS Research News : Paediatric Multiple Sclerosis Research - http://www.msrc.co.uk/index.cfm?fuseaction=show&pageid=1408